Santa Margherita Ligure is a comune in the Metropolitan City of Genoa in the Italian region Liguria, located about 35 kilometres southeast of G…Santa Margherita Ligure is a comune in the Metropolitan City of Genoa in the Italian region Liguria, located about 35 kilometres southeast of Genoa, in the area traditionally known as Tigullio. It has a port, used for both tourism and fishing activities. Part of comune territory is included in the Regional Natural Park of Portofino. Santa Margherita Ligure borders the following municipalities: Camogli, Portofino, Rapallo.