Guadalupe is a municipality of Spain located in the province of Cáceres, Extremadura. It has a total area of 68.19 km² and, as of 1 January 20…Guadalupe is a municipality of Spain located in the province of Cáceres, Extremadura. It has a total area of 68.19 km² and, as of 1 January 2021, a registered population of 1,822. The monastery of Santa María de Guadalupe is situated here.