The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster is too strong for that. However, this is a team that is falling apart and they have a few glaring issues that can be exposed by the right team.

It wasn't just the Seahawks celebrating Thursday's night win. The 49ers now have a path to the NFC West title, too.

It’s been a much different year for the 49ers, who have dealt with major injuries on both sides of the ball, including season-ending ones for Nick Bosa and Fred Warner. Still, they’re sitting at 10-4 with a chance to get the NFC’s No. 1 seed, should they win their final three games of the season.

The Indianapolis Colts have gone 1-5 in their last six games. Key players at impact positions are now out, and the team is sputtering to the finish line. They are significant underdogs to the San Francisco 49ers despite being at home on Monday Night Football in Week 16.

A lot of the 49ers' biggest contributors weren't on the team last year. Heck, some of them weren't even on the team in Week 1.

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 at Lucas Oil Stadium.

Fortunately for the Colts, one of those players is trending upward as the Colts prepare for a Monday Night Football matchup against the San Francisco 49ers at Lucas Oil Stadium. The Colts had two key starters miss Friday's practice due to injury, but most of the roster participated in the team's second practice of the week.

Tight end George Kittle's wife has partnered with Smirnoff to continue bringing high spirits to the suite amid all the NFL madness

Three-time Super Bowl Champion, former San Francisco 49ers tight end Brent Jones joined "You've Got Mail" presented by Delta Dental to discuss his induction to the Edward J. DeBartolo Sr. 49ers Hall of Fame,

This article was originally published on www.si.com/nfl/49ers/onsi as John Lynch Dismisses “Injury-Prone” Label for This 49ers Player. Despite a staggering number of injuries on both sides of the ball, the San Francisco 49ers haven’t allowed it to define their season.