AMP-activated protein kinase (AMPK) regulates metabolism by sensing changes in the AMP:ATP ratio in eukaryotic cells. The binding of AMP to AMPK and activation of its Ser/Thr protein-kinase domain ...

Researchers devised a process to convert a skin cell directly into a neuron, eliminating the need to generate induced pluripotent stem cells. Such neurons could be used to treat spinal cord injuries ...

This graphic illustration of a study in Cell ... cells, AMPK, is required for astrocytic glycoses, lactate production and lactate shuttle to bio-energize neurons. Loss of AMPK causes neuron ...

Human embryonic stem cells could provide a valuable source or replacement neurons to ameliorate the effects of neural disorders such as Parkinson's disease, but the majority of such cells do not ...

A recently launched Phase 1 clinical trial is examining the safety and feasibility of a groundbreaking treatment approach for Parkinson's disease in which a patient's stem cells are reprogrammed to ...

A new process for converting skin cells to neurons directly could make it easier to develop therapies for neurodegenerative disorders.

While this group of colorful neurons was grown in a dish from stem cells, in the body neurons like this are responsible for sensing pain. There is a specialized subset of sensory neurons called ...