The PEG layer on micellar surfaces can reduce nonspecific protein adsorption while potentially hindering the adsorptive endocytosis (or cellular uptake) of associated oligonucleotide payloads.

Internalization by adsorptive endocytosis, an energy-dependent, saturable process: including clathrin-mediated endocytosis, not including caveolae-mediated endocytosis NS [ 77 ] ...

Internalization by adsorptive endocytosis, an energy-dependent, saturable process: including clathrin-mediated endocytosis, not including caveolae-mediated endocytosis NS [ 77 ] ...