For decades, CD4+ T-cells were seen to have a primarily supportive role in the immune response to cancer, priming CD8+ T cells that would take the more active role in attacking cancer cells. However ...

During infections, the immune system needs to distinguish foreign antigens that are expressed by invading bacteria and ...

Now researchers at La Jolla Institute for Immunology (LJI) have discovered new genes in CD4+ "helper" T cell subset that are linked to risk of autoimmune diseases. Skip to content. Menu.

CD4+ T cells, or helper T cells, are one type of lymphocyte that helps coordinate the immune response against infection and disease. The cells are crucial in achieving a regulated effective immune ...

As they work to shed light on the exact functions of new CD4+ T cell subsets, the researchers have uncovered major differences between donors based on genetics and how the cells may function in ...

The molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "double positive" CD4+-CD8+ T cells have lately been ...

The immune system's killer T cells are crucial in fighting viral infections. A fraction of them - memory cells - live on once infection is controlled in order to fight re-infection by the same virus.

Their latest study, published recently in PLOS Pathogens, reveals how a subset of CD4+ "helper" T cells may help a person fight CMV and reduce the chances of the virus spreading from person to person.

Before COVID-19 vaccination, CD4+ T cells also comprised cross-reactive T cell populations. Their frequency had a weak correlation post-first vaccination in older adults.

Their latest study, "Late-rising CD4 T cells resolve mouse cytomegalovirus persistent replication in the salivary gland," published in PLOS Pathogens, reveals how a subset of CD4 + "helper" T ...