The CD40–CD40 ligand (CD40L) interaction is key to the maturation of functional T and B cells. To inhibit this interaction in the context of autoimmunity, Karnell and colleagues generated a ...

CD40 is a transmembrane protein belonging to the tumor necrosis factor receptor superfamily. It is predominantly expressed on antigen-presenting cells like B cells, macrophages, and dendritic cells.

The CD40–CD40L costimulatory pathway regulates adaptive and innate immune responses and has been implicated in the pathogenesis of multiple sclerosis. Frexalimab is a second-generation anti-CD40L ...

CHATHAM, N.J. and MIAMI, April 09, 2025 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP), (“Tonix”) a fully-integrated biopharmaceutical company with marketed products and a ...

Frexalimab, an investigational second-generation CD40 ligand (CD40L) inhibitor, led to fewer new gadolinium-enhancing T1-weighted lesions in relapsing multiple sclerosis (MS), a phase II trial showed.

Predictors of Specialized Pediatric Palliative Care Involvement and Impact on Patterns of End-of-Life Care in Children With Cancer Three CD40L SNPs (rs3092920, rs3092952, rs3092936) were analyzed for ...

Bristol Myers Squibb has exercised its option to globally license Obsidian Therapeutics' CD40L-armed cell therapy. The deal gives Bristol Myers control of a drug designed to counter the ...

CHATHAM, N.J., Oct. 14, 2025 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (“Tonix” or the “Company”), a fully integrated biotechnology company with marketed products and a ...

Topline results expected in the third quarter of 2024; planning a Phase 2 Trial for prevention of kidney transplant rejection Anti-CD40L has multiple possible indications in addition to solid organ ...

Sanofi has laid down a marker in the race to revitalize an approach to treating autoimmune diseases. More than 20 years after a pre-merger Biogen and Idec independently raised safety concerns about ...

Predictors of Specialized Pediatric Palliative Care Involvement and Impact on Patterns of End-of-Life Care in Children With Cancer Endothelial vulnerability is a potential risk factor for ...