Here the authors show that, in mouse tumors, CD8 + T cells with a low-avidity TCR are the mediators of antitumor and immunotherapy responses, in part because T cells with a high-avidity TCR are ...

creating a comprehensive CD8+ T cell atlas with paired T cell receptor (TCR) information. They found associations between CD8+ T cell subtypes, characterized three distinct exhausted T cell ...

can be used to quantitate and to sort CD8-independent T cells. Developing high-affinity soluble antibody molecules endowed with a TCR-like specificity toward tumor epitopes, termed TCR-like antibodies ...

The CD8+ T cell activation involves two key interactions: The TCR/pMHCI interaction: determines antigen specificity. Promiscuity is a characteristic feature of this interaction and it is essential for ...