Apoptosis, a process important for clearing ... A primary responder in this pathway is caspase-8, known to be recruited via its Death effector domains (DEDs) to the activated DRs to form a complex ...

Researchers have characterised how dying, or necrotic, cells contribute to the body’s regeneration process, with potential implications for wound and tissue repair.

A recent study has unveiled the pivotal role of Ferroptosis Suppressor Protein 1 (FSP1) in intervertebral disc degeneration ...

To showcase practical application, the researchers connected the perceptein circuit's output to a caspase-3 apoptosis pathway. This linkage allowed the circuit to trigger cell death based on ...

Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark of apoptosis initiation—with fluorescent dyes. Researchers often perform multiplex caspase assays ...

Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1) is a ubiquitin-binding protein that is widely ...

The primary interest of our lab is to investigate the molecular mechanisms of apoptosis and how they impact human ... disk confocal microscope to perform single cell analysis of caspase pathways.

The FDA has granted orphan drug designation to PEP-010 for pancreatic cancer, advancing its development as a potential novel ...

Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1 ...