Macbecin II was identified as a compound that upregulates MHC-I expression, enhancing immune-mediated cancer cell killing. In ...

Moffitt Cancer Center researchers have discovered a promising new vaccine strategy for treating a specific type of breast ...

Figure 1: Three pathways for loading major histocompatibility complex (MHC) class II molecules with peptides in dendritic cells. The presence of empty class II molecules on the surface of ...

Do allogeneic dendritic cells offer an advantage? Figure 3: Direct CD4 + T-cell allorecognition for provision of T-cell help for the generation of self-MHC restricted T-cell responses to tumor ...

Shortly after transplantation, skin dendritic cells (DCs ... the direct pathway, in which T cells recognize intact donor MHC antigens on donor DCs; and the indirect pathway, involving T-cell ...

As the researchers demonstrate, dendritic cells that are marked by expression of the transcription factor RORγt—so-called RORγt + dendritic cells (DCs)—are found in many tissues. Moreover ...

As part of the innate immune system, dendritic cells are in the body's first line of defense against infections. They detect pathogens and coordinate the immune response. An international team led ...

Following skin transplantation, cutaneous dendritic cells ... graft APCs (bone marrow-derived MHC class II + cells) migrate to the draining lymph nodes of the recipient where they can activate ...