Figure 1: Three pathways for loading major histocompatibility complex (MHC) class II molecules with peptides in dendritic cells. The presence of empty class II molecules on the surface of ...

Dendritic cells (DC) 'prime' tumor antigen-specific cytotoxic T lymphocytes; thus, we investigated whether DC might also trigger the innate, NK cell-mediated anti-tumor immunity. In mice with MHC ...

A study led by the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), in collaboration with the Instituto ...

Following skin transplantation, cutaneous dendritic cells ... graft APCs (bone marrow-derived MHC class II + cells) migrate to the draining lymph nodes of the recipient where they can activate ...

The immune system must be able to rapidly target invaders such as viruses while avoiding innocuous stimuli, or allergies may develop.

Shortly after transplantation, skin dendritic cells (DCs ... the direct pathway, in which T cells recognize intact donor MHC antigens on donor DCs; and the indirect pathway, involving T-cell ...