Endocytosis occurs when the cell membrane engulfs particles (dark blue) outside the cell, draws the contents in, and forms an intracellular vesicle called an endosome. This vesicle travels through ...

Cell biologists have been intrigued by endocytosis ever since Ilya Metchnikoff described the phenomenon of phagocytosis, a form of endocytosis that uses vesicles to internalize solid particles.

In addition to its role in endocytosis, the clathrin machinery also forms stable structures called flat clathrin lattices. We recently discovered that these structures are essential for the ...