Adaptive immunity establishes long-term immunological ... such as the major histocompatibility complex (MHC), which in turn can signal to T- and B-cells to mature and survive.

MHC class I polymorphisms define the characteristic ... with problems such as vaccine immunogenicity, vector-specific immunity, HIV sequence diversity and viral adaptation to effective CD8 ...

Kwangseog Ahn of Seoul National University led a group that purified protein complexes associated with MHC class I loading and found protein disulfide isomerase (PDI) in the mix of peptides. 1 PDI ...

Peptide antigen/MHC I complexes are presented on the cell ... Because DNA vaccines generate cell-mediated immunity, the hope is that they will be effective against some difficult viruses even ...

Finding these (via MHC molecules) alerts T cells that the tumor ... lipoplex neoantigen vaccines to induce durable, functional immunity (after surgery) in one of the most treatment-resistant ...