V(D)J recombination is a fundamental genetic mechanism that underpins the adaptive immune response in jawed vertebrates. This process orchestrates the rearrangement of variable (V), diversity (D) and ...
In a recent study published in Nature Communications, researchers described an approach to edit the recombination-activating gene 2 (RAG2) locus for therapeutic applications. Study: CRISPR-Cas9 ...
RAG deficiencies encompass a spectrum of inherited disorders arising from mutations in the recombination-activating genes, RAG1 and RAG2, that are pivotal for V(D)J recombination. This essential ...
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