“But our enzyme is one enzyme that does four things.” The team named the enzyme bilirubin reductase (BilR). Next, they explored how widespread BilR was across bacteria. They searched the Genome ...

Statins belong to the prescription drug class called hydroxymethylglutaryl-coenzyme A (HMG CoA) reductase enzyme inhibitors. They work to reduce the production of cholesterol in the liver.

Figure 1: Structures of the Fd–FNR complex and PDR. Figure 3: NMR chemical shift perturbation of Fd upon complex formation with FNR. Figure 4: Structural perturbation of FNR induced by complex ...

The statins lower LDL-C by inhibiting an enzyme, HMG-CoA reductase, that catalyzes the rate-limiting step in the synthesis of mevalonate, a cholesterol precursor. This results in reduction of ...