A nerve biopsy involves the process of removing a small length of a peripheral nerve for histologic ... a properly processed nerve biopsy must include semi-thin sections and teased nerve fiber ...

According to a case–control study published in Neurology, the expression of proinflammatory cytokines is elevated in the affected skin of patients with small-fiber neuropathy (SFN).

“We could already quantify small sensory fibers using intra-epidermal nerve fiber density (IENFD ... staining or preparation of the skin biopsy is required, allowing the SGNFD technique to ...