Pain is an important physiological response in living organisms. While physical pain is an outcome of tissue damage, pain can ...

Toll-like receptors (TLRs) use multiple downstream signaling pathways. New data suggest that components of the tumor necrosis factor receptor signaling pathway are involved in signal transduction ...

Intracellular Signaling Pathways Activated by TNF Receptors TNF signaling through TNFR1 and TNFR2 can elicit a variety of cellular responses depending on many factors including the metabolic state ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how single-cell RNA sequencing reveals that Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the ...

The tumor necrosis factor (TNF)-α/NF-κB-signaling pathway plays a pivotal role in various processes including apoptosis, cellular differentiation, host defense, inflammation, autoimmunity and ...

There is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium ...

A University of Minnesota Medical School-led research team has discovered that a cancer signaling pathway has previously ...

Both necroptosis and apoptosis pathways participated in the TNF + LT-triggered IEC deaths and mouse death. Inhibition of p38α mitogen-activated protein kinase (MAPK) signaling by LT in IECs ...

Researchers have uncovered a surprising connection between a cancer-related signaling pathway and the blood-brain and blood-retina barriers.

A study conducted by researchers at the Center for Cell-Based Therapy (CTC) highlights key proteins and signaling pathways ...

Signaling through TNFR2 activates inflammatory and pro-survival signaling pathways through recruitment of TRAF1 and TRAF2 adaptor proteins and subsequent activation of cIAPs and the NF-κB pathway ...