BACKGROUND: Thromboembolic events, including myocardial infarction (MI) or stroke, caused by the rupture or erosion of unstable atherosclerotic plaques are the leading cause of death worldwide.

Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase. Animal studies have demonstrated ...

Aim: This executive summary of the clinical practice guideline for the evaluation and diagnosis of chest pain provides recommendations and algorithms for clinicians to assess and diagnose chest pain ...

BACKGROUND: Viral cardiac infection represents a significant clinical challenge encompassing several etiological agents, disease stages, complex presentation, and a resulting lack of mechanistic ...

Although the primary cardiology team can initiate evaluation, treatment, and longitudinal care, referral to multidisciplinary hypertrophic cardiomyopathy (HCM) centers with appropriate expertise can ...

Background— The relationship of circulating levels of high-sensitivity C-reactive protein (CRP) with cardiovascular disease (CVD) risk, particularly with consideration of effects at intermediate ...

Beginning in this issue of Circulation, we present two new features designed to enhance the transfer of information to our clinician readers. First, you will notice that the cover includes a new box ...

Valvular repair or replacement is a common final management option in both primary and secondary MR, resulting in ≈50 000 annual mitral valve operations in the United States; however, defining the ...

Background Clonidine has an antihypertensive effect by its action in the brain and, because we observed that the tonic production of nitric oxide (NO) in the brain is required to maintain blood ...

Atrial fibrillation (AF), the most common sustained arrhythmia, represents a difficult scientific challenge and remains enigmatic even after more than a century of research. Already about a 100 years ...

Although mechanistic pathways have been discovered, it is unknown how these and as of yet unknown mediators of preeclampsia can impact fetal heart development and their long-term consequences in the ...