Injuries stacked up quickly for the San Francisco 49ers leading up to their Week 3 showdown with the Los Angeles Rams. Running back Christian McCaffrey was already on IR with Achilles tendinitis,

The Los Angeles Rams (0-2) are 6.5-point underdogs in a home NFC West matchup with the San Francisco 49ers (1-1) on Sunday, September 22, 2024 at SoFi Stadium.NFL odds courtesy of BetMGM

According to Tallysight, a whopping 96% of experts are picking the 49ers to beat the Rams. It’s slightly better when factoring in the spread where the Rams are getting between 6.5 and 7.5 points, but only 35% of experts are taking them to cover the spread as underdogs.