Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

New Activin R-based medications can emerge as perfect solutions for balancing weight loss and muscle building, making a ...

The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. This is an important study providing evidence of a Numb ...

Neuroscientists have identified that the receptor IL-1R1 plays a critical role in enabling neurons to directly communicate with the immune system. The new study provides the most detailed mapping of ...

Bone regeneration research has taken a significant leap forward with the discovery of a crucial mechanism that could ...

As the year unfolds the biotech industry will look closely at these ten first-in-class drugs on track to reach FDA approval ...

Delve into the increasingly dynamic landscape of ALS treatment development with thirteen companies advancing candidates in 2025.

A novel geometric deep learning framework designs ligand-specific protein binders, enhancing therapeutic potential in cell ...

Tongue Cancer Organoids Reveal Secrets of Chemotherapy Resistance Jan. 9, 2025 — Tongue cancer (TC) cells can enter a chemo-resistant state by activating pathways related to autophagy and ...

Cartalax peptide, a bioregulator derived from cartilage tissue, has garnered significant interest in scientific communities ...

T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent ...