Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation -- and relocation -- as they fight infections in the small intestine.

Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor ...

The three-dimensional shape of a protein can be used to resolve deep, ancient evolutionary relationships in the tree of life, ...

MURA-8518 is designed to be a half-life extended, binding protein-resistant IL-18 in order to overcome ... nemvaleukin treatment leads to preferential expansion of antitumor CD8+ T cells and natural ...

You can get them from certain foods. Amino acids, often referred to as the building blocks of proteins, are compounds that play many critical roles in your body. You need them for vital processes ...

This important manuscript presents a thorough analysis of trans-specific polymorphism (TSP) in Major Histocompatibility Complex gene families across primates. The analysis makes the most of currently ...

Proteinuria is the presence of too much protein in the urine. It is typically a sign of kidney disease, often in people diagnosed with diabetes, but also can occur with pregnancy, lupus, and other ...

In line with this, it was recently shown that a systemic acute virus infection leads to infiltration of CD8 T cells in the brains of immunocompetent mice. In this study, we extend these findings to ...

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Oncolytic adenoviruses were designed to reach potent intratumoral T-cell activation via expression of bifunctional-T-cell ...