“This causes a metabolic phenotype that resembles a glutamine synthetase deficiency, which can be characterized by increased ...

Research shows mitochondria form distinct subpopulations under nutrient stress, revealing survival mechanisms in cancer cells ...

The purine/purinergic system has emerged as a fundamental regulator of cellular communication, influencing various physiological processes such as metabolism, energy balance, and signal transduction.

This study presents valuable insights into the organization of second-order circuits for gustatory neurons, particularly how they integrate opposing taste inputs and the metabolic states that regulate ...

Liver failure encompasses a range of severe clinical syndromes resulting from the deterioration of liver function, triggered ...

As an outcome, several drugs, such as Metformin, Itraconazole, Pimozide, and Disulfiram, were repurposed to regulate metabolic and EMT pathways. Moreover, strategies such as combination therapy, ...

Methods: In this study, a glutamate-induced oxidative stress damage model of R28 ... its mechanism revealed that baicalin effectively inhibits the JAK/STAT signaling pathway, protecting RGCs from ...

But against this backdrop, change is afloat. Here in northeastern Alberta, Pathways Alliance seeks a proving ground. Pathways Alliance, a group of the six largest oilsands companies, is planning to ...

adaptive metabolic changes, and aging. "Given the high conservation of TGF-β signaling, manipulating TGF-β pathways to coordinate mitochondrial stress responses and promote healthy aging in ...

What are inherited metabolic disorders? Inherited metabolic disorders — also known as inborn errors of metabolism — are heritable, or genetic, disorders. There are hundreds of known inborn errors of ...