CD47-amyloid-β-CD74 signaling is a key driver of adaptive immunosuppression in sepsis, suppressing B cells and impairing immunity. Blocking this pathway restores immune function and improves survival ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by ...

In sepsis and atherosclerosis, DC ferroptosis contributes to immunosuppression. MDSCs, which suppress immune responses, have subtypes with varying ferroptosis resistance. Tumor-associated MDSCs ...

Meningococcal disease is a severe, fast-progressing infection; vaccination is key for high-risk groups, preventing life-threatening complications like sepsis, brain damage, or death. Read on to know ...

Most cases of nocardiosis start out as lung infections, in which pus-filled cavities, or abscesses containing the bacteria, form in the lungs. This can cause symptoms such as chest pain, a cough ...

Acute respiratory distress syndrome (ARDS) continues to be a tough nut to crack in critical care, taking lives despite years of research and better ventilator strategies. It is defined by acute ...

Sepsis induces a period of immunosuppression which can be problematic in the face of subsequent infectious challenge. Here the authors show the presence of PD-L1 expressing regulatory plasma cells ...

Acute respiratory distress syndrome (ARDS) continues to be a tough nut to crack in critical care, taking lives despite years of research and better ...

Pediatric critical care remains a pivotal frontier in modern medicine, confronting unique challenges shaped by the dynamic physiology and developmental ...