Research has identified a specific function for K63-linked ubiquitination in signaling pathways, particularly in tumor necrosis factor (TNF)–induced NF-κB activation 5.

Intracellular Signaling Pathways Activated by TNF Receptors TNF signaling through TNFR1 and TNFR2 can elicit a variety of cellular responses depending on many factors including the metabolic state ...

Smad6 inhibits IL-1 receptor and Toll-like receptor signaling; thus, it has an inhibitory function analogous to that of Smad7 in the TNF signaling pathway 9.

A research team led by Prof. Liu Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Science has ...

The bispecific antibody market is experiencing rapid growth, primarily driven by the increasing prevalence of complex chronic diseases, such as cance ...

Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and ...

When ocrelizumab became the first FDA-approved treatment for early forms of multiple sclerosis (MS) in 2017, it offered ...

This review explores the potential of punicic acid in pomegranate seed oil as a nutraceutical for cardiovascular health.

DelveInsight's Rheumatoid Arthritis Pipeline report depicts a robust space with 75+ active players working to develop 80+ ...

Most shockingly, diquat was dubbed “the worst offender” of the four weed killers. “It is 200 times more chronically toxic ...

From drug trials to mechanistic insights, EULAR 2025 delivers wide-ranging data that may inform tomorrow’s standards in ...