Tumor necrosis factor (TNF) is a proinflammatory cytokine that plays a critical role in diverse cellular events, ... (TRADD), another critical molecule in the TNF signaling pathway.

Toll-like receptors (TLRs) use multiple downstream signaling pathways. New data suggest that components of the tumor necrosis factor receptor signaling pathway are involved in signal transduction ...

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become ...

Intracellular Signaling Pathways Activated by TNF Receptors . TNF signaling through TNFR1 and TNFR2 can elicit a variety of cellular responses depending on many factors including the metabolic ...

A University of Minnesota Medical School-led research team has discovered that a cancer signaling pathway has previously ...

Elderly AML patients as expected had worse overall survival and event-free survival compared with younger patients. Analysis of oncogenic pathways revealed that older patients had higher probability ...

Shi’s study, "Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling," was recently published in Nature Communications. “Concerted efforts ...

Functional enrichment analysis highlighted pathways such as the C-type lectin receptor signaling pathway, tumor necrosis factor signaling pathway, and hypoxia-inducible factor-1 signaling pathway.

Monday, January 27, 2025. News & Perspective Drugs & Diseases CME & Education Video Decision Point Drugs & Diseases CME & Education Video Decision Point ...