Medically reviewed by Femi Aremu, PharmD Benadryl (diphenhydramine) is an over-the-counter (OTC) antihistamine that is commonly used to treat allergy symptoms, like sneezing, itching, and hives ...

Antihistamines may be able to calm a stress rash, depending on how your body adapts to stress. ... Antihistamines, such as Benadryl, Claritin, or Zyrtec, block histamine receptors, ...

Do try an antihistamine like Benadryl at bedtime. Look for the word “diphenhydramine” on the label. Even if it doesn’t relieve the itch, it might help you sleep better.

Since Benadryl was introduced in the 1940s, safer antihistamines have been developed, ... (CSACI) warns against Benadryl as a first-line treatment for hay fever and hives in adults and children.