The EGF signaling pathway regulates cell growth, proliferation, differentiation, and survival through the activation of EGFR and downstream cascades like RAS/RAF/MEK/ERK and PI3K/AKT.

Furthermore, activation of the EGFR pathway by administrating epidermal growth factor (EGF) to the parental lines TPC-1 and FRO before they acquired resistance induced a decrease in lenvatinib ...

Signaling pathways in mammalian cells are assembled and regulated by a finely controlled network of protein–protein and protein–phospholipid interactions, mediated by dedicated signaling ...

To investigate the expression of sonic hedgehog (SHH) and epidermal growth factor receptor (EGFR) signal molecules in pancreatic cancer cells, and to assess the inhibitory effects through the ...

EGFR is a receptor on the surface of cells which is expressed in many normal epithelial tissues, including skin. The EGFR signaling pathway is one of the key pathways that regulate growth ...

We have discovered EGFR-dependent signaling pathways that control the types of membrane protrusions that form during cell adhesion which recapitulates the earliest stages of cell migration. Some of ...

Cisplatin is a potent chemotherapeutic agent used to treat various cancers, including cervical cancer. But the continued use of cisplatin can lead to the development of cisplatin resistance and other ...

The epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signaling pathway, frequently hyperactivated in CRC, drives tumor growth, but its downstream effectors ...

Background: Determination of the mutational status of key gene effectors along the EGFR signaling pathway plays a critical role in the management of metastatic colorectal cancer (mCRC) and other ...

This research demonstrates a signaling pathway that can be activated by different methods and could represent a new approach to cochlear regeneration and, ultimately, restoration of hearing.

EGFR is a receptor on the surface of cells which is expressed in many normal epithelial tissues, including skin. The EGFR signaling pathway is one of the key pathways that regulate growth ...