And the relationship of HDCA mediating the Epiregulin (EREG)/Epidermal Growth Factor Receptor (EGFR) signaling pathway through FXR was explored. Eight pairs of primary CRC and paracancerous tissue ...

Both EGF-family ... in signal attenuation. It is useful to distinguish between general attenuation, which functions at the level of the ligand–receptor complex, and pathway-specific inactivation ...

This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of ... Scientific), 1 mM N-acetyl-L-cysteine (Sigma-Aldrich), 50 ng/mL EGF (PeproTech, Inc., ...

It is clear that aside from EGF, other ligands of the family, including Neuregulin 1 (NRG1), have distinct roles in supporting the function of intestinal stem cells through the ErbB pathway. Figure 2.

Although many of the major downstream signaling pathways that KRAS engages have been defined, these discoveries have yet to translate into effective targeted therapy. Much of the current focus has ...