Researchers describe, for the first time, the full molecular cascade that comprises acrosomal exocytosis, an essential step in fertilization, in this week's PLoS Biology. "Exocytosis has been analyzed ...

Robust control of exocytosis is critical for all cells to ... It does that by talking to the membrane fusion protein." More information: Chanwoo Lee et al, Exocyst stimulates multiple steps ...

If binding directly stimulates steps in exocytosis and also activates signal ... As with other pore-forming toxins, an initially soluble protein is converted into a membrane-inserted pore ...

proteins. Our team has conducted the first genome-wide CRISPR screens to systematically identify new regulators of regulated exocytosis—a type of vesicle fusion—in mammalian cells. These screens ...

SYT7 and SYT9 act as calcium sensors in fast synaptic and neuroendocrine exocytosis. Mammals express several other SYTs, including SYT10, but the functions of these proteins are unknown.

Regulated exocytosis involves the fusion of specialized vesicles ... cardiovascular disorders and neurological disorders to chronic inflammatory diseases. G protein coupled receptors (GPCRs) represent ...