Xerosis is the most common cause of pruritus without an accompanying rash, and it can be associated with inflammatory skin diseases including atopic dermatitis, systemic diseases such as ...

Up until now, immune cells and the inflammatory ... chronic condition atopic dermatitis," says Isaac Chiu, an immunologist at Harvard Medical School. "We show that itch can be caused by the ...

"The recent regulatory feedback from the EMA builds on the previous positive interactions with the FDA while providing a roadmap for TH104 for chronic pruritus in PBC, which continues to be a ...

The molecule's dual mechanism of action targets both the µ-opioid and kappa-opioid receptors and may inhibit IL-17 inflammatory cytokine expression, which is implicated in the body's itch circuitry.