Research Progress on Ferroptosis Mechanism in Endometrial Cancer. Journal of Biosciences and Medicines, 13, 65-74. doi: 10.4236/jbm.2025.137005 . Endometrial Cancer (EC) is an epithelial malignant ...

Researchers have uncovered a surprising connection between a cancer-related signaling pathway and the blood-brain and blood-retina barriers.

A University of Minnesota Medical School-led research team has discovered that a cancer signaling pathway has previously ...

The bispecific antibody market is experiencing rapid growth, primarily driven by the increasing prevalence of complex chronic diseases, such as cance ...

The metabolism of bone tumors is extraordinarily complex and involves many signaling pathways and processes, including the tumor necrosis factor (TNF) signaling pathway, which consists of TNF factors ...

Intracellular Signaling Pathways Activated by TNF Receptors TNF signaling through TNFR1 and TNFR2 can elicit a variety of cellular responses depending on many factors including the metabolic state ...

TNF signaling contributes significantly to pathology of constitutively active STING in murine STING-associated vasculopathy with onset in infancy disease.

Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become ...

The binding of the Egr/TNF to Grnd triggers an apoptotic response through the dTRAF2-JNK signaling pathway. In response to Egr-dependent and independent stimuli, Wgn associates with different dTRAFs ...

Mechanistically, Kindlin-2 loss abnormally activates the tumor necrosis factor (TNF) pathway. Blocking activation of the TNF signaling pathway by deleting TNF receptor or deletion of Caspase 8 ...

Shi’s study, "Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling," was recently published in Nature Communications. “Concerted efforts ...