Defensive coordinator Robert Saleh and offensive coordinator Klay Kubiak discussed the team's matchup prep, highlighted key ...

It can be tempting for the San Francisco 49ers to overlook the Indianapolis Colts this week. After starting the season 7-1, ...

It looks like the Indianapolis Colts are rolling with Philip Rivers again for their Monday night matchup against the San Francisco 49ers in Week 16. That gives us another interesting slate of bets to ...

The 49ers running game has been up and down, but they could have an advantage against a very solid Colts run defense ...

Yardbarker NFL writers identify the MVP for every NFL team, weighing on-field impact, consistency and importance to overall success.

The Indianapolis Colts will be front and center when they try to pull off the upset against the San Francisco 49ers.

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, 2025.

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

Colts’ Jonathan Taylor; Ricky Pearsall Jr. doesn’t practice but Kyle Shanahan likes his chances to play Monday.

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, ...

Let’s keep the streak going. We have found some success with our NFC West Bold Predictions, but now the heat is on. The Los ...

Lucas Oil Stadium is the location where the Indianapolis Colts (8-6) will meet the San Francisco 49ers (10-4) on Monday.