Vacuoles containing mitochondria are marked with asterisks. Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following …

Since the timely removal of abnormal mitochondria is essential for cell survival, cells have evolved a variety of mitophagy pathways to ensure that mitophagy can be activated in time under …

Nov 30, 2023 · Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and recycles damaged mitochondria and regulates the biogenesis of new, fully …

Sep 13, 2023 · Mitophagy is a selective form of macroautophagy (hereafter "autophagy") that cells use to degrade mitochondria. During mitophagy, mitochondria are selectively sequestered …

Jan 13, 2021 · Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Here, we provide an update on mechanisms that control mitophagy, its role in aging and therapeutic interventions that harness mitophagy to treat age-related disorders.

Mar 26, 2020 · In this review, we summarize recent findings on mechanisms controlling mitophagy and its role in aging and the development of human pathologies. Mitochondria are highly …

Aug 16, 2023 · Here, we summarize the signaling pathways and mechanisms that regulate mitophagy. Furthermore, we discuss how alterations in mitophagy affect mitochondrial …

Killackey et al. review recent advances and major questions in the field of mitophagy, as well as implications for mitophagy in disease. Mitophagy is an evolutionarily conserved process …

May 17, 2024 · Mitophagy is a specialised form of autophagy, that is an evolutionarily conserved mechanism, which allows the degradation and recycling of mitochondria by lysosomes [2]. …