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  1. What Is Ketamine? How It Works and May Help With Severe Depression - WebMD

    Jan 31, 2025 · Is ketamine a treatment for depression? What are the risks? Learn about the uses, benefits, and side effects of ketamine.

  2. Ketamine For Depression: What You Need To Know - Mayo Clinic Press

    Dec 19, 2022 · In the past, there was speculation that ketamine masked depression by making a person feel “high.” This theory has since been debunked. Ketamine doesn’t remain in the system very long, …

  3. New Study Raises Questions About Ketamine for Depression

    Oct 25, 2025 · The recent randomized controlled trial compared intravenous ketamine to midazolam (an active placebo) in patients hospitalized for moderate to severe depression.

  4. Ketamine for Depression: How It Works | News | Yale Medicine

    Mar 18, 2024 · In this video, Yale Medicine psychiatric specialists discuss how ketamine can help treat depression.

  5. Ketamine could treat depression by interacting with the brain's …

    Jul 24, 2025 · Ketamine is a highly effective, fast-acting antidepressant that works even for patients who have not responded to other medications. However, the brain mechanisms important for these rapid …

  6. Rapid relief for the severely depressed? There’s a catch.

    Nov 20, 2024 · A recent clinical trial found that ketamine was as effective for non-psychotic treatment-resistant depression as electroconvulsive therapy (ECT), which has long been the gold standard for …

  7. Ketamine and rapid antidepressant action: new treatments and

    Jul 24, 2023 · In this review, we discuss key clinical aspects of ketamine’s effect as a rapidly acting antidepressant, synaptic and circuit mechanisms underlying its action, as well as how these novel...

  8. What To Know About Ketamine for Depression - Yale New Haven …

    May 30, 2025 · Ketamine has gained in popularity as a treatment for drug-resistant depression. Find out how it works and who might be a good candidate.

  9. Ketamine for the treatment of major depression: a systematic review …

    Aug 3, 2023 · This meta-analysis confirmed prior findings that ketamine is effective for treating depression and racemic ketamine may be more effective than esketamine. Dosage was shown to be …

  10. What Is Ketamine and Is It Effective for Depression? | U.S. News

    What Is Ketamine and Is It Effective for Depression? Find out what ketamine is, how ketamine therapy is used to treat depression, what side effects it can have and more.