Steven A. Siegelbaum Principal Investigator We are interested in the molecular and cellular mechanisms underlying electrical signaling and synaptic transmission in the nervous system, and how these electrical signals give rise to complex behaviors.

Steven Siegelbaum, PhD, is leading efforts to understand how electrical signals in the brain encode memories that can last a lifetime, and how changes to these signals play a role in psychiatric disorders.

The Siegelbaum lab studies how electrical signaling and synaptic plasticity in defined neural circuits processes information to encode social memory, an animal’s ability to recognize and recall another individual of its own species.

One area of research explores the role of the hyperpolarization-activated cation channels (the HCN channels) in regulating dendritic integration of excitatory and inhibitory synaptic inputs.

Dr. Siegelbaum is leading efforts to understand how electrical signals in the brain encode memories that can last a lifetime, and how changes to these signals play a role in psychiatric disorders.

Dr. Siegelbaum is leading efforts to understand how electrical signals in the brain encode memories that can last a lifetime, and how changes to these signals play a role in psychiatric disorders.

Steven A. Siegelbaum PDF Download PubMed Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome

Steven A. Siegelbaum's 198 research works with 21,906 citations and 15,134 reads, including: Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the...

View the profile of Steven A. Siegelbaum, PhD, Former Investigator at HHMI from Columbia University.

Jan 6, 2009 · Dr. Siegelbaum, a member of the P&S faculty since 1981, is professor of neuroscience and pharmacology and an investigator of the Howard Hughes Medical Institute. He has been serving as vice chair of the Department of …